Accuracy of fFN Test in Predicting Preterm Labor

How accurate is fFN test?
Combination of fFN and cervical length does not seem to increase the predictive accuracy of both tests taken separately. A positive fFN testing increases the individual PTB probability from 7.5% to 66.1%, due to its high positive likelihood ratio of 24, whereas a negative test decreases it to 2.4%.
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Premature birth and other difficulties for both the mother and the child can result from preterm labor, which is a severe worry for pregnant women. The fetal fibronectin (fFN) test is one of many diagnostic techniques used by medical practitioners to stop premature labor. However, how precise is the fFN test? Let’s investigate.

The fetal fibronectin (fFN) test is a diagnostic technique that finds the presence of the protein that secures the embryonic sac to the uterine lining, fetal fibronectin. Between weeks 22 and 35 of pregnancy, if the protein is discovered in vaginal secretions, it means that the sac is separating from the uterus, which may result in premature labor. The test is not without flaws, and its accuracy varies according to gestational age and other variables.

According to studies, there is a minimal chance of preterm labor occurring in the next two weeks if the fFN test is negative. This is because the test has a strong negative predictive value. However, because the test has a lower positive predictive value, a positive result does not always signify preterm labor. In actuality, up to 50% of women with fFN positivity do not experience premature labor.

The gestational age is another element that influences the fFN test’s accuracy. When the pregnancy is between 24 and 34 weeks, the test is most accurate. The test is unreliable before 24 weeks since the majority of pregnant women’s cervical secretions include fetal fibronectin. The test is useless after 34 weeks because there is less chance of a preterm birth.

In terms of timing, the fFN test can deliver prompt and precise findings in less than 24 hours. This enables medical providers to administer tocolytic medications as necessary to prevent preterm labor.

Drugs called tocolytics can slow down or stop contractions, which helps to avoid preterm labor. They function by decreasing inflammation and relaxing the uterine muscles. Tocolytic medications have negative effects, though, and they don’t always work to stop preterm labor.

A woman must experience consistent contractions, cervical dilation of more than 2 cm, and cervix effacement in order to test positive for premature labor. In addition, in women who have symptoms like vaginal bleeding, cramping, or pelvic pressure, the fFN test can identify the possibility of preterm labor.

Finally, the risk of preterm labor can also be predicted by the cervical length at 20 weeks of pregnancy. Preterm delivery is more likely in women with cervical lengths under 25 mm. Therefore, doing regular measurements of cervical length throughout pregnancy can assist identify women who are at risk and enable them to take preventive action.

In conclusion, the fFN test is an effective method for anticipating preterm labor, however it has drawbacks and its precision varies with different variables. In order to prevent preterm labor in high-risk women, medical practitioners should use the test in conjunction with other diagnostic tools and take the necessary precautions.